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KMID : 1145520210070010003
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Journal of Radiopharmaceuticals and Molecular Probes
2021 Volume.7 No. 1 p.3 ~ p.10
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Preliminary research on the development of boron neutron capture therapy drugs
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Kim So-Yeon
Yang Ji-Ung
Lee Kyo-Chul
Kim Jung-Young
Lee Yong-Jin
Park Ji-Ae
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Abstract
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For successful boron neutron caputre therapy, it is essential to develop a boron drug with a selective accumulation capacity for tumors. In particular, in order to apply boron neutron caputre therapy to brain tumors, drugs with good blood-brain barrier penetration are required. In this study, two low-molecular-weight boron compounds were introduced as brain tumor boron neutron caputre therapy drugs, and their physical and biological efficacy were evaluated. Among them, B2 showed good blood-brain barrier permeability and a high brain/blood ratio. From these results, it is expected that B2 can be used as a useful boron drug for boron neutron caputre therapy in brain tumors.
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KEYWORD
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Boron neutron caputre therapy, Brain tumor, Blood-brain-barrier, Boron drugs
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